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http://hdl.handle.net/2239/33160
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| Title: | Vulgarone B, the antifungal constituent in the steam-distilled fraction of Artemisia douglasiana. |
| Authors: | Meepagala, K.M.
Kuhajek, J.M.
Sturtz, G.D.
Wedge, D.E.
USDA, ARS |
| Keywords: | vulgarone
Artemisia
Asteraceae
essential oils
sesquiterpenoids
antifungal agents
antifungal properties
chemical structure
structure-activity relationships
Colletotrichum
Colletotrichum acutatum
Glomerella cingulata
Botrytis cinerea
plant pathogenic fungi |
| Issue Date: | 17-Oct-2007 |
| Description: | Antifungal activity of the steam distilled essential oil fraction of Artemisia douglasiana was detected by bioautography on silica gel TLC plates against three Colletotrichum spp. The active principle was isolated by bioassay-directed fractionation using column chromatography followed by crystallization and was characterized as vulgarone B by 1H and 13C NMR and GC-MS. Antifungal activity of vulgarone B was further evaluated using 96-well microtiter assay against Colletotrichum acutatum, C. fragariae, C. gloeosporioides, and Botrytis cinerea. In addition, the antifungal activity of vulgarone B and verbenone, and their corresponding alcohols was tested by bioautography and microtiter assay. Structure-activity studies revealed that the α, β-unsaturated carbonyl functionality is a prerequisite for the antifungal activity of these mono and sesquiterpene ketones. This is the first report of antifungal activity of vulgarone B. The yield of essential oil from A. douglasiana is about 0.6-0.8% by weight of the dry material, including plant stems. |
| URI: | http://seekspace.resip.ac.cn/handle/2239/33160 |
| Other Identifiers: | http://seekspace.resip.ac.cn/handle/10113/2709 |
| Appears in Collections: | 网络开放学术资源
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