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http://hdl.handle.net/2239/33884
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| Title: | Zinc absorption and kinetics during pregnancy and lactation in Brazilian women. |
| Authors: | Donangelo, C.M.
Vargas Zapata, C.L.
Woodhouse, L.R.
Shames, D.M.
Mukherjea, R.
King, J.C.
USDA, ARS |
| Keywords: | maternal nutrition
pregnancy
pregnant women
lactating women
lactation stage
dietary minerals
zinc
nutrient intake
nutrient availability
intestinal absorption
urination
kinetics
Brazil |
| Issue Date: | 17-Oct-2007 |
| Description: | Background: Adjustments in zinc absorption and endogenous excretion maintain zinc homeostasis in nonpregnant adults fed low-zinc diets. The effects on zinc homeostasis of a low zinc intake during pregnancy and lactation have not been described in a longitudinal study. Objective: We examined longitudinal changes in fractional zinc absorption (FZA) and zinc kinetics in 10 healthy Brazilian women who habitually consumed a marginal zinc diet (approximately equal to 9 mg Zn/d). Design: Zinc status was measured at 10-12 (early pregnancy; EP) and 34-36 (late pregnancy; LP) wk of pregnancy and at 7-8 wk after delivery (early lactation; EL). Zinc kinetics and FZA were studied by using stable isotopic tracers. Results: Zinc intake averaged 9 +/- 3 mg/d throughout the study. FZA increased from 29 +/- 6% at EP to 43 +/- 10% at LP and to 39 +/- 13% at EL (P < 0.05). FZA was inversely related to plasma zinc at EL (r = -0.73, P = 0.02) and LP (r = -0.72, P = 0.07). Plasma zinc mass was 23% greater at LP than at EP or EL (P < 0.05). The amount of zinc (mg/d) that fluxed between plasma and the most-rapidly-turning-over extravascular pool was 53% greater at LP than at EP or EL (P < 0.05). The zinc flux between plasma and the less-rapidly-turning-over zinc pool at EL was 27% greater than that at EP or LP, but this difference was not significant. Conclusions: FZA increased significantly in women with marginal zinc intakes during pregnancy and lactation; the increase was higher in women with low plasma zinc. Plasma zinc was distributed into a different exchangeable pool at LP than at EL. |
| URI: | http://seekspace.resip.ac.cn/handle/2239/33884 |
| Other Identifiers: | http://seekspace.resip.ac.cn/handle/10113/2018 |
| Appears in Collections: | 网络开放学术资源
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